Many chemical variations of mescaline and amphetamine have been synthesized for their "feel good" effects. MDMA (Ecstasy) is the most popular and widely abused variation used today.

DOM (4-Methyl-2,5-dimethoxyamphetamine) was introduced to the San Francisco drug scene in the late 1960's and given the nickname "STP," an acronym for "Serenity, Tranquility, and Peace." Doses of 1 to 3 milligrams generally produce mood alterations and minor perceptual alterations while larger doses can produce pronounced hallucinations that last from 8 to 10 hours.

Other illicitly manufactured analogues include 4-bromo-2,5-dimethoxyamphetamine (DOB), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 4-bromo-2,5-dimethoxyphenethylamine (2C-B, NEXUS). These drugs differ from one another in their potency, speed of onset, duration of action, and their capacity to modify mood with or without producing overt hallucinations. The drugs are usually taken orally but are sometimes snorted or injected (rarely). Because they are produced in clandestine laboratories, they are seldom pure and the amount of the drug in a capsule or tablet is likely to vary considerably.

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